Author

Giles A. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Aleksandra AzevedoiD· 2 shared Anna TasegianiD· 2 shared Colin T. R. DaviesiD· 2 shared Dominic D. G. OwensiD· 2 shared Liliana GregeriD· 2 shared Louise Kelly ModisiD· 2 shared Marta CarraraiD· 2 shared Martin Pass· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Aleksandra AzevedoORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Identification and SAR optimization of FBXO22-mediated TEAD Targeted Glue degraders

Martin Fisher, Alice Fletcher, Callum Hamby, Jack Miles, Martin Ambler, Aleksandra Azevedo, Sara Bisetto, Colin T. R. Davies, Pauline Drouhin, Liliana Greger, Scott J. Hughes, Martin O'Rourke, Dominic D. G. Owens, Paula MacGregor, Wojciech J. Stec, , Marta Carrara

This study identifies and optimizes TEAD-targeted glue degraders using an aldehyde-mediated degron mechanism, achieving improved degradation potency and kinetics.

bioRxiv · Sep 10, 2026 · PreprintCancer Biology

Selective degradation of BRD9 by a DCAF16-recruiting targeted glue: mode of action elucidation and in vivo proof of concept

Scott J. Hughes, Wojciech J. Stec, Colin T. R. Davies, David McGarry, Alicia Williams, Marta Carrara, Iván del Barco Barrantes, Rebecca Harris, Anna Tasegian, Dominic D. G. Owens, Alexander Fawcett, John Hellicar, Aleksandra Azevedo, Gregor P. Meier, Andrew C. Runcie, , Andrea Testa

The paper identifies a potent BRD9 degrader, AMPTX-1, which selectively recruits BRD9 to DCAF16, leading to its degradation in vivo.

Nature Communications · Oct 27, 2025Peer-reviewedBiochemistry

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to 1 CA1 by differential modulation of feedforward inhibitory circuits

Jon Palacios-Filardo, Matt Udakis, Giles A. Brown, Benjamin Gerald Tehan, Miles Congreve, Pradeep J. Nathan, Alastair Brown, Jack R. Mellor

This study shows acetylcholine equally depresses excitatory inputs from entorhinal cortex and CA3 in CA1 but enhances overall activation by preferentially depressing feedforward inhibition from entorhinal cortex.

Nature Communications · Sep 16, 2021Peer-reviewedNeuroscience