Jack R. Mellor

Coordinated acetylcholine release and adaptation of neuronal representations in the retrosplenial cortex during contextual uncertainty

The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.

Inhibition of cortico-amygdala projections underlies affective bias modification by psilocybin

This study identifies modulation of the prelimbic cortico-amygdala circuit by psilocin as key to affective bias modification and antidepressant effects in a rodent model.

Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping

This study shows that OLM interneurons inhibit synaptic plasticity and influence place cell remapping by modulating dendritic calcium signaling in the hippocampus.

Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations

This study investigates how reward location variability affects hippocampal spatial representations by inducing reorganization in place cell populations under different uncertainty conditions.

Analysis of Hippocampal Synaptic Function in a Rodent Model of Early Life Stress

This study examines the effects of early life stress on hippocampal NMDAR function in rats, finding altered AMPA/NMDA ratios without changes in LTP.

GluK2 Q/R editing regulates kainate receptor signalling to modulate AMPA receptor synaptic expression and plasticity

This study shows that GluK2 Q/R editing affects KAR signaling balance, impacting AMPA receptor expression and synaptic plasticity in mice.

Reduced expression of the psychiatric risk gene DLG2 (PSD93) impairs hippocampal synaptic integration and plasticity

This study shows that reduced DLG2 expression in rats impairs hippocampal synaptic integration and plasticity, which can be reversed by muscarinic M1 receptor agonists.

Behavioural and molecular characterisation of the Dlg2 haploinsufficiency rat model of genetic risk for psychiatric disorder

This study characterizes the Dlg2 haploinsufficiency rat model, finding reduced PSD-93 expression and specific behavioral changes linked to psychosis vulnerability without other deficits.

Investigation of reward learning and feedback sensitivity in non-clinical participants with a history of early life stress

This study investigates reward learning and feedback sensitivity in adults with a history of early life stress, finding deficits in positive feedback sensitivity and reward learning compared to controls.

Acetylcholine boosts dendritic NMDA spikes in a CA3 pyramidal neuron model

The paper uses a computational model of CA3 pyramidal neurons to show acetylcholine enhances dendritic excitability and reduces the number of synapses needed to generate NMDA spikes.

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to 1 CA1 by differential modulation of feedforward inhibitory circuits

This study shows acetylcholine equally depresses excitatory inputs from entorhinal cortex and CA3 in CA1 but enhances overall activation by preferentially depressing feedforward inhibition from entorhinal cortex.

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

This study shows that sustained kainate receptor activation reduces AMPA receptor surface expression and induces hippocampal long-term depression.

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

The paper shows that inhibitory synapses from parvalbumin and somatostatin interneurons undergo distinct forms of long-term plasticity that shape hippocampal network activity and spatial representations.

A Bayesian predictive approach for dealing with pseudoreplication

The paper introduces a Bayesian predictive approach to address pseudoreplication in biological research, demonstrating its effectiveness with two in vivo datasets.

Acetylcholine disinhibits hippocampal circuits to enable rapid formation of overlapping memory ensembles

The paper shows acetylcholine enhances memory encoding in the hippocampus by disinhibiting circuits and enabling overlapping memory ensembles during salient events.