Interpretable machine learning coupled to gene regulatory networks uncovers subcircuits underlying cell fate decisions
Zarifeh Heidari Rarani, Swapnil Keshari, Akanksha Sachan, Ankur Singh Saini, Nicholas A. Pease, Jingyu Fan, Alayna Fu, Yuchen C Liu, Aditi U. Gurkar, Greg M. Delgoffe, Harinder Singh, Jishnu Das
FOCAL couples interpretable machine learning with gene regulatory networks to identify regulatory subnetworks underlying cell fate decisions in B and T cells.
bioRxiv · Sep 29, 2026 · PreprintSystems Biology