Greg M. Delgoffe

FOCAL couples interpretable machine learning with gene regulatory networks to identify regulatory subnetworks underlying cell fate decisions in B and T cells.

This study shows ATR kinase inhibitors cause mitochondrial fission and impair immune memory in CD8+ T cells during viral infection.

This study identifies phosphoethanolamine as a key metabolite in tumor interstitial fluid that suppresses T cell function by inhibiting TCR signaling.

This study shows that zinc availability in the tumor microenvironment affects anti-PD1 therapy response in CDKN2A-low tumors through macrophage phagocytosis.

The paper shows engineered destabilization of viral proteins enhances T cell recognition, improving vaccine efficacy against KSHV and SARS-CoV-2.