Nicholas A. Pease

This study identifies an ISRE/EICE motif lexicon that distinguishes IRF4 and BLIMP1 binding during plasma cell differentiation, revealing a temporally ordered regulatory mechanism.

FOCAL couples interpretable machine learning with gene regulatory networks to identify regulatory subnetworks underlying cell fate decisions in B and T cells.

This study shows Blimp1 restricts clonal dominance in germinal center B cells by controlling chromatin accessibility and BCR signaling during the light-to-dark zone transition.

The paper expands the DNA motif lexicon of transcriptional regulatory code by identifying composite elements and using a deep learning model to predict their activity and impact of variants.

The paper shows that delaying Bcl11b activation via an epigenetic switch increases ILC generation and reduces T cell output in the thymus by redirecting progenitors at the T/ILC branchpoint.

The paper introduces SCEPTRE, a method combining expansion microscopy with histone modification analysis to study chromatin states in single cells at high resolution.

The paper identifies an epigenetic timer mechanism that controls temporal scaling in developmental gene networks, enabling flexible size control through delayed activation of key regulators.