Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations
Andreas Damianou, Zhu Liang, Frederik Heymann Lassen, George Vere, Svenja Hester, Philip D. Charles, Adán Pinto-Fernández, Alberto Santos-Delgado, Roman Fischer, Benedikt Mathias Kessler
The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.
bioRxiv · Nov 23, 2021 · PreprintMolecular Biology