Svenja Hester

The paper identifies human antibodies against a mosquito salivary protein, SG1L3, that binds to Plasmodium falciparum sporozoites but does not block infection.

This study uses time-resolved proteomics to analyze host protein changes during early HBV infection, revealing coordinated proteome alterations and specific complement pathway dynamics.

This paper develops a spatial pharmacology workflow using LCM-LC-PRM to profile MMAE distribution in tumour and healthy tissues, revealing heterogeneous and time-dependent accumulation patterns.

This study investigates the role of lysosomal Ca2+ signaling in heart rhythm and atrial function, finding that NAADP pathway inhibition affects SAN pacemaker activity and cAMP production in atrial myocytes.

The paper identifies proteomic signatures of mitochondrial dysfunction in goats with atrial fibrillation, highlighting oxidative phosphorylation subunits and HSPA9 as a regulatory hub.

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

This study characterizes extracellular vesicles from activated CD4 T cells and shows their pro-inflammatory effects on antigen-presenting cells, providing a resource for EV-based therapeutic development.

This study shows that IP3R activation in atrial myocytes increases cAMP, which can be inhibited by IP3R blockers, but ventricular myocytes show cAMP increases independent of IP3R.

This study shows CDK9 and PP2A regulate RNA polymerase II transcription termination and RNA maturation by modulating polyadenylation and splicing factors.

The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.

The paper uses poly(A)+ RNA-protein crosslinking data in fission yeast to analyze RNA-protein complexes and their functional organization.

The paper investigates how RNA-binding proteins (RBPs) change in response to viral infection and identifies RBPs crucial for viral replication.