This study uses time-resolved proteomics to analyze host protein changes during early HBV infection, revealing coordinated proteome alterations and specific complement pathway dynamics.

DOI 10.64898/2026.02.24.707876

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 27, 2026

Menin maintains enhancer-promoter interactions in a leukemia-specific manner

Vassilena Sharlandjieva, Catherine Chahrour, Frederik Heymann Lassen…·Thomas A. Milne

The paper investigates Menin's role in enhancer-promoter interactions in MLL-rearranged and NPM1c leukemia models, finding context-dependent effects on transcriptional regulation and enhancer function.

DOI 10.64898/2026.01.16.698179

humanChIP-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintOct 7, 2024

Integrative Proximal-Ubiquitomics Profiling for Deubiquitinase and E3 Ligase Substrate Discovery Applied to USP30

Andreas Damianou, Hannah B. L. Jones, Athina Grigoriou…·Benedikt Mathias Kessler

The paper identifies direct substrates of the DUB USP30 using a proximal-ubiquitome workflow combining APEX2 and ubiquitination enrichment.

DOI 10.1101/2024.10.07.616967

proteomicsexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintNov 23, 2021

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

Andreas Damianou, Zhu Liang, Frederik Heymann Lassen…·Benedikt Mathias Kessler

The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.

3 citations

proteomicsexperimental assay

𝕏 PostBluesky