Roman Fischer

Spatial Tumour Tissue Distribution Dynamics of a Bicycle Peptide-MMAE Toxin Conjugate Profiled by Targeted Mass Spectrometry

This paper develops a spatial pharmacology workflow using LCM-LC-PRM to profile MMAE distribution in tumour and healthy tissues, revealing heterogeneous and time-dependent accumulation patterns.

A platform for deep topographic multiomic mapping of the bone marrow environment in multiple myeloma

The paper develops a spatial tri-omics workflow to map genetically distinct myeloma subclones in bone marrow, showing they occupy spatially and biologically distinct niches.

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in Mice

This study characterizes a novel mouse model of OA-induced heart failure, revealing sex-specific cardiac remodeling and molecular pathways associated with different HF phenotypes.

Thrombospondin Encapsulated Dense Particles accelerate wound healing and downregulate fibrotic phenotypes

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

The developmental environment mediates adult seminal proteome allocation in male Drosophila melanogaster

This study investigates how larval crowding affects seminal proteome allocation in Drosophila melanogaster males and females, finding that small males transfer more seminal proteins despite producing less overall.

Cerebral small vessel disease due to Col4a1 mutations include cognitive impairment and white matter defects that can be modulated by targeting protein folding.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

Adaptor protein 2 sigma subunit (AP2S1) variants associated with neurodevelopmental disorders

The paper identifies AP2S1 variants linked to neurodevelopmental disorders by showing they impair clathrin-mediated endocytosis and disrupt protein interactions.

Interplay Between KRAS and LZTR1 Protein Turnover, Controlled by CUL3/LZTR1 E3 Ubiquitin Ligase, is Disrupted by KRAS Mutations

The paper shows KRAS mutations disrupt its interaction with LZTR1, affecting protein stability via the CUL3 ubiquitin ligase complex, contributing to oncogenesis.

Kawasaki Disease patient stratification and pathway analysis based on host transcriptomic and proteomic profiles

This study stratifies Kawasaki Disease patients using transcriptomic and proteomic profiles, finding KD responses resemble bacterial infections but with distinct features suggesting alternative triggers.