Chronic activation of a negative engram induces behavioral and cellular abnormalities
Alexandra L. Jellinger, Rebecca L. Suthard, Bingbing Yuan, Michelle Surets, Evan A. Ruesch, Albit J. Caban, X. Shawn Liu, Monika Shpokayte, Steve Ramirez
This study shows that repeated activation of negative memory engrams in mice leads to lasting cellular and behavioral abnormalities, similar to chronic negative thinking in humans.
eLife · Apr 17, 2024Peer-reviewedNeuroscience