Bingbing Yuan

Polyamines buffer labile iron to suppress ferroptosis

This study shows polyamines buffer labile iron to suppress ferroptosis by linking polyamine metabolism to iron homeostasis through a genome-wide CRISPR screen and fluorescent reporter.

Systematic functional genetic analysis of cell-substrate adhesion

This study identifies gene targets involved in cell-substrate adhesion through functional genetic analyses in human cells, revealing dynamic requirements and novel regulators.

Functional genomic dissection of MS risk loci reveals convergence of cis and trans gene regulatory mechanisms in microglia

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

Chronic activation of a negative engram induces behavioral and cellular abnormalities

This study shows that repeated activation of negative memory engrams in mice leads to lasting cellular and behavioral abnormalities, similar to chronic negative thinking in humans.

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

Fragile X syndrome patient-derived neurons developing in the mouse brain show FMR1 -dependent phenotypes

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

Hippocampal cells multiplex positive and negative engrams

The paper identifies distinct cell populations in the ventral hippocampus that encode appetitive and aversive memories, showing molecular, cellular, and projection-specific differences.