X. Shawn Liu

This study shows that RTT astrocytes release dysfunctional mitochondria, disrupting neuronal activity and cerebral organoid development through impaired energy metabolism and mitochondrial dysfunction.

This study shows that repeated activation of negative memory engrams in mice leads to lasting cellular and behavioral abnormalities, similar to chronic negative thinking in humans.

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

The paper identifies distinct cell populations in the ventral hippocampus that encode appetitive and aversive memories, showing molecular, cellular, and projection-specific differences.