AGO CLIP reveals an activated network for acute regulation of brain glutamate homeostasis after ischemic stroke
Mariko Kobayashi, Corinne Benakis, Corey J. Anderson, Michael J. Moore, Carrie Poon, Ken Uekawa, Jonathan P. Dyke, John J. Fak, Aldo Mele, Christopher Y. Park, Ping Zhou, Josef Anrather, Costantino Iadecola, Robert B. Darnell
The paper uses AGO CLIP to identify miRNA-target interactions in the brain after ischemic stroke, revealing miR-29 family members lose target regulation, leading to rapid proteomic changes in glutamate homeostasis.
Cell Reports · Jul 1, 2019Peer-reviewedMolecular Biology