Author

Alec Lourenço

California Institute of Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Matt W. ThomsoniD· 2 shared Arjuna M. SubramanianiD· 1 shared Camille Dahlgren· 1 shared Eric D. ChowiD· 1 shared Jael Santos· 1 shared Jiapei MiaoiD· 1 shared Lucas Garcia· 1 shared Maya Kapur· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Matt W. ThomsonORCID

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2 papers

Recent·Most cited

Protein CREATE enables closed-loop design of de novo synthetic protein binders

Alec Lourenço, Arjuna M. Subramanian, Ryan K. Spencer, Michael A. Anaya, Jiapei Miao, William Fu, Eric D. Chow, Matt W. Thomson

Protein CREATE generates and tests synthetic protein binders using a closed-loop computational-experimental pipeline, identifying novel binders and binding features.

bioRxiv · Dec 20, 2024 · PreprintBioengineering

Design of Novel Dehalogenases using Protein Large Language Models

Lucas Garcia, Willow Nauber, Camille Dahlgren, Ray Chung, Troy Reyes, Jael Santos, Maya Kapur, Monica Barsever, Matt W. Thomson, Alec Lourenço

High school students designed novel dehalogenases using large language models to degrade PFOA, a persistent PFAS compound, and plan to test their enzymatic activity.

bioRxiv · Oct 28, 2024 · PreprintBioengineering