Astrocytic FMRP regulates the function of spinal parvalbumin-expressing neurons in Fragile X Syndrome
Haoyi Qiu, Rian Fritz Jalandoni, Ann Derham, Nolan Reinisch, Catherine Chen, Alec Vong, Erik P. Cook, Arjun Krishnaswamy, Anmar Khadra, Reza Sharif‐Naeini
This study identifies astrocytic FMRP loss as the cause of spinal parvalbumin neuron dysfunction in FXS, revealing astrocyte-dependent circuit disruption.
bioRxiv · Jul 19, 2026 · PreprintNeuroscience