Reza Sharif‐Naeini

The paper develops a stochastic HH model to study intrinsic ionic mechanisms driving spontaneous firing in spPVINs, revealing how Ih and noise contribute to irregular bursting and circuit inhibition.

The paper identifies endosomal dysfunction in a murine model of Christianson Syndrome as a cause of inhibitory circuit hyperexcitability through KCC2 mistrafficking.

The paper identifies a novel subset of IL-1R1+ nociceptors in mice using multimodal transcriptomics and calcium imaging, revealing their role in inflammatory pain.

This study shows nerve injury shifts spinal circuit recruitment from inhibitory to excitatory parvalbumin interneurons, causing mechanical allodynia.

This study identifies astrocytic FMRP loss as the cause of spinal parvalbumin neuron dysfunction in FXS, revealing astrocyte-dependent circuit disruption.

The paper maps molecular features of human spinal cord dorsal and ventral horns, identifying neuronal types and sex-specific glial differences using single-nucleus sequencing and spatial transcriptomics.

Senolytic drugs reduce low back pain by eliminating senescent cells and decreasing inflammatory factors in the intervertebral disc and spinal cord.

This study shows that mouse dLGN has systematic visual field biases in feature selectivity, influenced by cortical feedback.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

This study investigates how chronic pain alters the rewarding value of gentle touch in mice by examining neural circuits and behavioral responses.

ElecFeX provides a user-friendly MATLAB-based toolkit for efficient feature extraction from single-cell electrophysiological recordings, enabling streamlined analysis of large datasets.

This study identifies a calcium-dependent mechanism that modulates spinal dorsal horn PVINs' electrical activity after nerve injury, showing that impaired calcium buffering increases SK channel activity and reduces intrinsic excitability.

This study shows that parvalbumin protein (PVp) buffers calcium to maintain tonic firing in PV neurons, and its reduction after nerve injury leads to mechanical allodynia.

The paper identifies TACAN as an essential subunit of the mechanosensitive ion channel responsible for mechanical pain sensing.