Haoyi Qiu

The paper develops a stochastic HH model to study intrinsic ionic mechanisms driving spontaneous firing in spPVINs, revealing how Ih and noise contribute to irregular bursting and circuit inhibition.

The paper identifies endosomal dysfunction in a murine model of Christianson Syndrome as a cause of inhibitory circuit hyperexcitability through KCC2 mistrafficking.

This study shows nerve injury shifts spinal circuit recruitment from inhibitory to excitatory parvalbumin interneurons, causing mechanical allodynia.

This study identifies astrocytic FMRP loss as the cause of spinal parvalbumin neuron dysfunction in FXS, revealing astrocyte-dependent circuit disruption.

ElecFeX provides a user-friendly MATLAB-based toolkit for efficient feature extraction from single-cell electrophysiological recordings, enabling streamlined analysis of large datasets.

This study identifies a calcium-dependent mechanism that modulates spinal dorsal horn PVINs' electrical activity after nerve injury, showing that impaired calcium buffering increases SK channel activity and reduces intrinsic excitability.

This study shows that parvalbumin protein (PVp) buffers calcium to maintain tonic firing in PV neurons, and its reduction after nerve injury leads to mechanical allodynia.