Systematic, Protein Activity-based Characterization of Single Cell State
Lukas J. Vlahos, Aleksandar Obradović, Jeremy Worley, Xiangtian Tan, Andrew Howe, Pasquale Laise, Alec Wang, Charles G. Drake, Andrea Califano
The paper introduces PISCES, a platform that improves single-cell analysis by estimating protein activity's role in cell state, validated with experimental assays and applied to human tissue data.
bioRxiv · May 20, 2021 · PreprintSystems Biology