Author

Andrew Howe

University of GenevaORCID 0000-0003-2187-7672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alec Wang· 1 shared Aleksandar ObradovićiD· 1 shared Andrea CalifanoiD· 1 shared Andreas BolandiD· 1 shared Charles G. DrakeiD· 1 shared Chloe M. GhentiD· 1 shared David O. MorganiD· 1 shared Francis J. O’ReillyiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperSystems Biology

Alec Wang

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2 papers

Recent·Most cited

BiochemistryScience AdvancesPeer-reviewedNov 12, 2025

Substrate recognition by human separase

Jun Yu, Sophia Schmidt, Margherita M. Botto…·Andreas Boland

This study determines cryoEM structures of human separase in apo and substrate-bound forms, revealing substrate recognition mechanisms and cleavage regulation.

4 citations

humancryo-EM

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 20, 2021

Systematic, Protein Activity-based Characterization of Single Cell State

Lukas J. Vlahos, Aleksandar Obradović, Jeremy Worley…·Andrea Califano

The paper introduces PISCES, a platform that improves single-cell analysis by estimating protein activity's role in cell state, validated with experimental assays and applied to human tissue data.

26 citations

humanscRNA-seq

𝕏 PostBluesky