Pasquale Laise

The paper identifies Dclk1-expressing cells in the pancreas and reveals their role in inhibiting pancreatic tumor progression through a tuft cell-ILC2 axis.

The paper identifies master regulator dependencies in coexisting diffuse midline glioma subpopulations and shows that combination therapy targeting these regulators improves survival in vivo.

The paper introduces PISCES, a platform that improves single-cell analysis by estimating protein activity's role in cell state, validated with experimental assays and applied to human tissue data.

The paper identifies host cell Master Regulator proteins hijacked by SARS-CoV and identifies drugs that can target these proteins to disrupt viral replication.

The paper identifies four molecularly distinct glioblastoma subtypes using single-cell protein-activity analysis and shows drug sensitivity is state-dependent.