CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti-tumoral compounds
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, María J. Barrero, Diego Megı́as, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez-Domínguez, Sara Monzón, Isabel Cuesta, Laura E. Sanchez, Rodrigo Barderas, , Ignacío Pérez de Castro
This study uses CRISPR to eliminate the FOXL2 c.402C>G mutation in granulosa tumor cells, reducing malignancy and identifying anti-tumoral compounds.
Molecular Oncology · Jan 8, 2025Peer-reviewedCancer Biology