Diego Megı́as

This study identifies podoplanin's role in maintaining epidermal organisation and coordinating stem cell and dermal responses during inflammatory skin remodelling.

This study investigates how Z-AAT accumulation in AATD models affects lipid metabolism, mitochondrial function, and organelle homeostasis, revealing impaired adaptive responses to lipid challenges.

This study uses adenine base editing to correct the LMNA c.745C>T mutation in myoblasts, showing improved cellular phenotype but also revealing harmful bystander mutations.

This study establishes thresholds for azole tolerance and persistence in Aspergillus fumigatus and shows tolerance negatively affects voriconazole treatment efficacy in a Galleria mellonella model.

This study identifies Ca-alpha1T and Slowpoke channels as essential for pro-tumorigenic Ca2+ signaling in Drosophila gliomas, with Slowpoke showing therapeutic potential.

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

This study uses CRISPR to eliminate the FOXL2 c.402C>G mutation in granulosa tumor cells, reducing malignancy and identifying anti-tumoral compounds.

The paper identifies PP2A-B55alpha,delta phosphatase as counteracting Ki67-dependent chromosome individualization during mitosis in mice.

The paper introduces a new method for micro-device fabrication using a laser scanning confocal microscope and photosensitive resins, enabling rapid, cost-effective, and accessible microfluidic device creation in standard laboratories.

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.