Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor
Brandon Sit, Allen G. Sanderlin, Alejandro A. Guzman, Lauren E. Bird, Clara Y. Zhu, Patrick J. Woida, Paige N. McCaslin, Julia Kevil-Yeager, Paige E. Allen, Jason A. Carlyon, Mary M. Weber, Thomas Burke, John G. Doench, Rebecca L. Lamason
This study identifies cyclophilin A as a host factor critical for the maturation and function of a virulence factor in obligate intracellular bacteria, with implications for therapeutic targeting.
bioRxiv · Oct 28, 2025 · PreprintMicrobiology