Paige E. Allen

Transformation and allelic exchange in Orientia tsutsugamushi

This paper develops a genetic transformation and allelic exchange protocol for Orientia tsutsugamushi, enabling genetic manipulation of this pathogen to study its biology and interactions with host cells.

Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor

This study identifies cyclophilin A as a host factor critical for the maturation and function of a virulence factor in obligate intracellular bacteria, with implications for therapeutic targeting.

Obligate intracellular Orientia tsutsugamushi impedes TP53 expression to inhibit DNA damage-induced apoptosis

This study shows that Orientia tsutsugamushi downregulates TP53 to block DNA damage-induced apoptosis and promote bacterial replication.