A genetic screen identifies O-antigen as essential for Rickettsia parkeri survival in macrophages by protecting from inflammasomes and interferon-stimulated genes
Han Sun, A. Guzman, Thomas Burke
bioRxiv · Jun 13, 2026 · PreprintMicrobiology
Author
Thomas Burke
University of California, IrvineORCID 0000-0002-1385-8757Unclaimed ORCID profile · follow to get notified of new preprints
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2025-2026 · peak 3/yrCo-Author Collaboration Network
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Curved chords = mutual co-authorship1 shared paperMicrobiology
A. Guzman
4 papers
Recent·Most cited
Host cyclophilin-mediated maturation of an obligate intracellular bacterial surface virulence factor
Brandon Sit, Allen G. Sanderlin, Alejandro A. Guzman, Lauren E. Bird, Clara Y. Zhu, Patrick J. Woida, Paige N. McCaslin, Julia Kevil-Yeager, Paige E. Allen, Jason A. Carlyon, Mary M. Weber, Thomas Burke, John G. Doench, Rebecca L. Lamason
This study identifies cyclophilin A as a host factor critical for the maturation and function of a virulence factor in obligate intracellular bacteria, with implications for therapeutic targeting.
bioRxiv · Oct 28, 2025 · PreprintMicrobiology
Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.
Panjaporn Chaichana, Naphat Satapoomin, Chitrasak Kullapanich, Suthida Chuenklin, Aisha Mohammad, Manutsanun Inthawong, Erin E. Ball, Thomas Burke, Piyanate Sunyakumthorn, Jeanne Salje
This study compares seven strains of Orientia tsutsugamushi to identify virulence factors, finding no single gene or pattern predicts virulence, but highlighting complex interactions among effector proteins.
PLoS Pathogens · Jun 30, 2025Peer-reviewedMicrobiology
Differences between human and rodent nitric oxide production dictate susceptibility to tick-borne Rickettsia.
Anh Phuong Luu, Alejandro Amando Guzman, Alexis Bouin, Nir Drayman, Thomas Burke
The paper identifies differences in nitric oxide production between human and rodent macrophages as a key factor in susceptibility to tick-borne Rickettsia.
bioRxiv · Jun 27, 2025 · PreprintMicrobiology