Dynamic-Structure Redesign of Calmodulin Reveals Mechanistic Constraints on Ryr2 Regulation
Vladimir Bogdanov, Svetlana B. Tikunova, Nicolas Fadell, Robyn T. Rebbeck, Melanie L. Aprahamian, Md Nure Alam Afsar, Aleksei Chekodanov, Daniel J. Blackwell, Björn C. Knollmann, Rǎzvan L. Cornea, Peter Michael Kekenes-Huskey, Steffen Lindert, Christopher N. Johnson, Sándor Györke, Jonathan P. Davis
The paper redesigns calmodulin to improve its function while preserving conformational dynamics, showing that structural flexibility is essential for physiological regulation.
bioRxiv · Apr 17, 2026 · PreprintBiophysics