BiophysicsbioRxivPreprint
Dynamic-Structure Redesign of Calmodulin Reveals Mechanistic Constraints on Ryr2 Regulation
Vladimir Bogdanov, Svetlana B. Tikunova, Nicolas Fadell…·Jonathan P. Davis
The paper redesigns calmodulin to improve its function while preserving conformational dynamics, showing that structural flexibility is essential for physiological regulation.
DOI 10.64898/2026.04.14.717973