BCKDK Inhibitors Directly Antagonize Angiotensin II Type 1 Receptor and Induce Vasodilation Independently of BCAA Catabolism or BCKDK
Ryo Kawakami, Yann Deleye, Esra Akkaya, Uyen Pham, Jae Woo Jung, Ling Lai, Anand Chundi, Srikrishna Darbha, Danielle Murashige, Ryan Gaspar, Wentao He, Guofang Zhang, Alem Kahsai, Sudarshan Rajagopal, Phillip James White, , Robert W. McGarrah
This study shows BCKDK inhibitors cause vasodilation by directly blocking the AT1R, independent of BCAA catabolism or BCKDK.
bioRxiv · Oct 11, 2026 · PreprintPhysiology