Wentao He

In Vivo Quantification of Histone Acetylation Turnover and Acetyl-CoA Sources Using 2H2O Metabolic Labeling and High-Resolution Mass Spectrometry.

This paper quantifies histone acetylation turnover and acetyl-CoA sources in vivo using 2H2O labeling and mass spectrometry, showing diet-dependent changes in acetylation dynamics and substrate contributions.

BCKDK Inhibitors Directly Antagonize Angiotensin II Type 1 Receptor and Induce Vasodilation Independently of BCAA Catabolism or BCKDK

This study shows BCKDK inhibitors cause vasodilation by directly blocking the AT1R, independent of BCAA catabolism or BCKDK.

Loss of Propionyl-CoA Carboxylase Reprograms Hepatic Metabolism by Suppressing Mitochondrial Pyruvate Carboxylation and Fatty Acid Oxidation

This study investigates metabolic changes in PCCA-deficient hepatocytes, showing reduced fatty acid oxidation and pyruvate carboxylation, leading to impaired gluconeogenesis and lipid synthesis.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.