Guofang Zhang

This paper quantifies histone acetylation turnover and acetyl-CoA sources in vivo using 2H2O labeling and mass spectrometry, showing diet-dependent changes in acetylation dynamics and substrate contributions.

This study shows BCKDK inhibitors cause vasodilation by directly blocking the AT1R, independent of BCAA catabolism or BCKDK.

The paper shows that ACLY depletion in obese mice paradoxically increases de novo lipogenesis despite reducing AcCoA levels, linked to increased SREBP1c expression.

This study identifies Slc1a5 as essential for osteoblast differentiation and bone development by facilitating glutamine and asparagine import in mice.