Albumin-coated VS1 nanocrystals enable STARD3 inhibition and potentiate fluoropyrimidine therapy in colorectal cancer
Isabella Caligiuri, Alessandro Bregalda, Gloria Saorin, Luisa M. R. Napolitano, Giulio Poli, Simona Kranjc, Urška Kamenšek, Miriana Di Stefano, Kirti Shila Sonkar, Juan Luis Pacheco‐García, Raghurama Hedge, Salvatore Parisi, Jane Budai, Muhammad Adeel, Carlotta Granchi, , Flavio Rizzolio
This paper develops albumin-coated nanocrystals to improve the solubility and delivery of the STARD3 inhibitor VS1, enhancing its synergistic effect with 5-FU in colorectal cancer.
bioRxiv · Jul 8, 2026 · PreprintCancer Biology