Author

Juan Luis Pacheco‐García

Universidad de GranadaORCID 0000-0001-6043-7536Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Angel Luis PeyiD· 2 shared Dmitry S. LoginoviD· 2 shared Pavla VaňkováiD· 2 shared Petr ManiD· 2 shared Alessandro Bregalda· 1 shared Atanasio Gómez‐MulasiD· 1 shared Barbara CelliniiD· 1 shared Carlotta GranchiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Angel Luis PeyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 8, 2026

Albumin-coated VS1 nanocrystals enable STARD3 inhibition and potentiate fluoropyrimidine therapy in colorectal cancer

Isabella Caligiuri, Alessandro Bregalda, Gloria Saorin…·Flavio Rizzolio

This paper develops albumin-coated nanocrystals to improve the solubility and delivery of the STARD3 inhibitor VS1, enhancing its synergistic effect with 5-FU in colorectal cancer.

DOI 10.64898/2026.07.07.737012

humanbulk RNA-seq

𝕏 PostBluesky

BiophysicsbioRxivPreprintApr 12, 2025

Nanobodies as therapies for loss-of-function misfolding diseases.

Atanasio Gómez‐Mulas, Mirco Dindo, Juan Luis Pacheco‐García…·Angel Luis Pey

This study develops and characterizes six nanobodies as potential therapeutics for PH1 by targeting misfolded AGT variants, showing high affinity and functional enhancement in cellular models.

DOI 10.1101/2025.04.12.648492

humanprotein structure

𝕏 PostBluesky

BiophysicsbioRxivPreprintFeb 2, 2025

Active site tyrosine residues in human NQO1 homodimer are critical for non-synchronous enzyme catalysis at the two active sites.

Maribel Rivero, Juan Luis Pacheco‐García, Pavla Vaňková…·Angel Luis Pey

This study investigates the role of Tyr126 and Tyr128 in human NQO1 catalysis, showing their critical impact on enzyme activity and non-synchronous catalysis.

DOI 10.1101/2025.02.02.636097

humanexperimental assay

𝕏 PostBluesky