Muscle stem cells in Duchenne muscular dystrophy exhibit molecular impairments and altered cell fate trajectories impacting regenerative capacity
Jules A Granet, Rebecca Robertson, Alessio A Cusmano, Romina L. Filippelli, Tim O Lorenz, Shulei Li, Moein Yaqubi, Jo Anne Stratton, Natasha C. Chang
This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.
Cell Death and Disease · Jun 5, 2025Peer-reviewedCell Biology