Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Alessio Vecchio, Fiorella Colasuonno, Luca Occhigrossi, Consuelo Pitolli, Veronica Bellanca, Fabio Ciccarone, Manuela D’Eletto, Federica Di Sano, Vittoria Pagliarini, Claudio Sette, Mauro Piacentini, Federica Rossin
This study shows that Transglutaminase 2 (TG2) promotes necroptosis by serotonylating H3K4me3 at the Ripk3 promoter, preventing its methylation and enabling Ripk3 expression.
Cellular and Molecular Life Sciences · Apr 9, 2025Peer-reviewedCell Biology