Cell BiologyCellular and Molecular Life SciencesPeer-reviewed
Epigenetic modulation of RIPK3 by Transglutaminase 2-dependent serotonylation of H3K4me3 affects necroptosis
Alessio Vecchio, Fiorella Colasuonno, Luca Occhigrossi…·Federica Rossin
This study shows that Transglutaminase 2 (TG2) promotes necroptosis by serotonylating H3K4me3 at the Ripk3 promoter, preventing its methylation and enabling Ripk3 expression.
9 citations