Endothelial AMBRA1 loss contributes to vascular dysregulation facilitating metastatic progression in early-stage melanoma
Laura Walker, Roisin Stout, Martina Di Rienzo, Katie Best, Sofia Bisegna, Luca Occhigrossi, Ioana Cosgarea, Philip Sloan, Grant Richardson, Raffaele Strippoli, Mauro Piacentini, Gian María Fimia, Penny E. Lovat, Jane L. Armstrong
This study shows that endothelial AMBRA1 loss leads to vascular dysfunction and promotes metastasis in early-stage melanoma.
bioRxiv · Sep 30, 2026 · PreprintCancer Biology