Multi-Pathway DNA Double-Strand Break Repair Reporters Reveal Extensive Cross-Talk Between End-Joining, Single Strand Annealing, and Homologous Recombination
Bert van de Kooij, Alex Kruswick, Haico van Attikum, Michael B. Yaffe
The paper introduces DSB-Spectrum reporters to analyze DNA repair pathway cross-talk and shows that DNA-PKcs inhibition increases SSA and HR, while end-resection factors influence pathway competition.
bioRxiv · Dec 22, 2021 · PreprintMolecular Biology