Bert van de Kooij

This study shows that CIP2A tetramerization is essential for mitotic DNA repair and survival of BRCA1/2 mutant cancer cells.

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

This study shows that CIP2A-TOPBP1 recruits the SMX tri-nuclease complex to resolve mitotic DNA lesions, ensuring genome integrity and survival of BRCA2-deficient cells.

This study identifies FANCL and Ube2T as HR-promoting factors at DSBs and shows they regulate CtIP recruitment and end-resection for homologous recombination.

This study shows that EXO1 is essential for survival of BRCA1-deficient cells and identifies it as a potential therapeutic target.

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

The paper introduces DSB-Spectrum reporters to analyze DNA repair pathway cross-talk and shows that DNA-PKcs inhibition increases SSA and HR, while end-resection factors influence pathway competition.