Evidence for a rod-to-cone lactate shuttle in the mammalian retina
Lan Wang, Wadood Haq, Lucia Peiroten, Alexander Hirsch, Catherine Hottin, Laimdota Zizmare, Yiyi Chen, Victor Calbiague, Paul Roberts, Oliver Schmachtenberg, Christoph Trautwein, François Paquet‐Durand
The paper demonstrates that lactate produced by rod photoreceptors supports cone photoreceptor function and viability through a rod-to-cone lactate shuttle, suggesting new therapeutic avenues for retinal diseases.
bioRxiv · Aug 25, 2026 · PreprintNeuroscience