Wadood Haq

The paper demonstrates that lactate produced by rod photoreceptors supports cone photoreceptor function and viability through a rod-to-cone lactate shuttle, suggesting new therapeutic avenues for retinal diseases.

This study investigates the effects of cGMP analogues targeting PKG on photoreceptor viability and function in a mouse model of autosomal dominant retinitis pigmentosa, finding neuroprotection and preserved retinal function.

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.

This study shows that inhibiting VCP activity rescues degenerating P23H rod cells and improves their function in retinal models of adRP.

This study shows HDAC inhibition delays cone death in RP mice by protecting multiple survival pathways, even after most rods have degenerated.

This study shows that IFN-γ and LRRK2 synergize in human neurons and microglia, leading to defects in neurite elongation and microglial activation.