François Paquet‐Durand

The paper demonstrates that lactate produced by rod photoreceptors supports cone photoreceptor function and viability through a rod-to-cone lactate shuttle, suggesting new therapeutic avenues for retinal diseases.

This study investigates how PARP regulates calpain activity in rd1 mouse photoreceptors and identifies potential therapeutic targets for inherited retinal degenerations.

This study investigates the role of PPARs and PGC-1α in photoreceptor neuroprotection in rd1 mouse model of retinal degeneration, finding that their activation reduces photoreceptor death and PARP activity.

This study identifies Esr1 activation as a protective mechanism against neuroinflammation in retinal degeneration, showing it suppresses Tnf-α signaling and reduces photoreceptor death.

This study shows that PARP inhibitors cause rod photoreceptor toxicity in a dominant RP mouse model, unlike in recessive RP, and highlights the need for careful use of these drugs in RP treatment.

This study investigates the effects of cGMP analogues targeting PKG on photoreceptor viability and function in a mouse model of autosomal dominant retinitis pigmentosa, finding neuroprotection and preserved retinal function.

This study evaluates the effects of HDAC inhibitors in an ADRP mouse model, finding that different inhibitors affect rod and cone photoreceptors variably, with MPT0G211 showing strong protection and ACY-957 causing cell death and proliferation.

This paper introduces a technique combining two-photon microscopy and multi-electrode array recordings to study the functional interaction between photoreceptors and retinal ganglion cells in acute retinal explants.

This paper introduces a novel mouse model of dominant retinitis pigmentosa caused by the RHO{Delta}I255 mutation, showing rapid photoreceptor degeneration, neuroinflammation, and disrupted neuronal connectivity.

This study investigates the role of calcium signaling in photoreceptor cell death in IRD using mouse models and identifies calpain-2 as a key contributor to degeneration.

This study uses scRNA-seq to analyze metabolic changes in mouse retinal cells during degeneration, identifying Ca2+-signaling and MAPK pathway involvement.

The paper demonstrates that calpain activity can be detected in live retinal tissue as a biomarker for retinal degeneration, showing distinct temporal activity patterns of calpain isoforms during photoreceptor cell death.

The paper identifies PKG substrates in retinal degeneration using kinome profiling and confirms their expression in specific retinal cell types.

This study shows that diltiazem enantiomers block Ca2+-influx in photoreceptors but do not prevent degeneration, challenging the role of Ca2+ in retinal degeneration.

This study develops a solid lipid nanoparticle formulation for efficient delivery of hydrophilic drugs to retinal cells, showing improved encapsulation efficiency and cellular uptake.

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.

This study shows HDAC inhibition delays cone death in RP mice by protecting multiple survival pathways, even after most rods have degenerated.

The paper maps spatio-temporal patterns of calpain activity in retinal degeneration models, linking Ca2+ dysregulation to primary rod death and apoptosis to secondary cone loss.