Mini-agrin prevents calcium leakage and restores the dystrophin complex.
Hitham Aldharee, Bartosz Mierzejewski, Alexander Kerr, Laricia Bragg, Anne Bigot, Judith R. Reinhard, Sabrina Santoleri, Neil A. Roberts, Raman M Das, Vincent Mouly, Markus A. Rüegg, Giulio Cossu, Francesco Galli
The paper shows mini-agrin prevents calcium leakage and restores the dystrophin complex in dystrophic muscle cells by stabilizing CaV1.1 and reconstituting dystrophin complex components.
bioRxiv · Nov 25, 2025 · PreprintCell Biology