Markus A. Rüegg

Laminin-α2 is required for the maintenance of the myotendinous junction in vivo

This study shows that laminin-α2 is essential for maintaining the myotendinous junction structure, and mechanical unloading affects its integrity in a mouse model of LAMA2-related muscular dystrophy.

c-MAF transduces fast motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions

This study identifies c-MAF as a mediator of motoneuron activity in maintaining fast-glycolytic muscle fibers and neuromuscular junctions through chromatin accessibility changes and gene regulation.

Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy

This paper describes a dual AAV gene therapy approach using linker proteins to restore basement membrane function in LAMA2 MD, showing significant improvements in muscle and nerve defects.

Loss of cell-autonomously secreted laminin-α2 drives muscle stem cell dysfunction in LAMA2-related muscular dystrophy

This study shows that laminin-α2 secreted by muscle stem cells is critical for their expansion and regeneration, and its loss leads to muscle stem cell dysfunction in LAMA2-related muscular dystrophy.

Mini-agrin prevents calcium leakage and restores the dystrophin complex.

The paper shows mini-agrin prevents calcium leakage and restores the dystrophin complex in dystrophic muscle cells by stabilizing CaV1.1 and reconstituting dystrophin complex components.

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance

The paper uses single-nuclei RNA-sequencing to identify NMJ-specific transcripts and shows that Etv4 and Pdzrn4 contribute to NMJ stability through gene regulation and protein interactions.

Muscle fiber Myc is dispensable for muscle growth and forced expression severely perturbs homeostasis

This study shows that muscle fiber Myc is not required for muscle growth but its overexpression disrupts muscle structure and function.

Fast, multiplexable and highly efficient somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9

This study develops a method to efficiently induce somatic gene deletions in adult mouse skeletal muscle fibers using AAV-CRISPR/Cas9, replicating knockout phenotypes without generating knockout mice.

Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy

This study shows that expressing two linker proteins in mouse models of LAMA2-related muscular dystrophy improves muscle function and prevents hindlimb paralysis.

mTORC1 signaling is not essential for the maintenance of muscle mass and function in adult sedentary mice

This study shows that mTORC1 inhibition in adult mice does not cause muscle atrophy or functional decline, despite metabolic and morphological changes.