Acute AMPK activation does not adequately stimulate insulin signaling in skeletal muscle models of Myotonic Dystrophy Type 1
Ofosu Adjei-Afriyie, Sally Spendiff, Ricardo Carmona-Martinez, Alexander Manta, Andreas Hentschel, Kelly Ho, Daniel O’Neil, Leanne Dawe, Andreas Roos, Vladimir Ljubicic, Alexander MacKenzie, Aymeric Ravel‐Chapuis, Hanns Lochmüller
This study shows that acute AMPK activation fails to improve insulin signaling in DM1 mouse and human models, indicating impaired insulin resistance mechanisms.
bioRxiv · Nov 4, 2025 · PreprintMolecular Biology