Author

Daniel O’Neil

University of OttawaORCID 0000-0002-9978-0101Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Daniel O’Neil1 paper · Genentech

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Hanns LochmülleriD· 2 shared Kelly HoiD· 2 shared Ofosu Adjei-AfriyieiD· 2 shared Ricardo Carmona-MartineziD· 2 shared Sally SpendiffiD· 2 shared Alexander MacKenzieiD· 1 shared Alexander Manta· 1 shared Andreas HentscheliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Hanns LochmüllerORCID

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2 papers

Recent·Most cited

Acute AMPK activation does not adequately stimulate insulin signaling in skeletal muscle models of Myotonic Dystrophy Type 1

Ofosu Adjei-Afriyie, Sally Spendiff, Ricardo Carmona-Martinez, Alexander Manta, Andreas Hentschel, Kelly Ho, Daniel O’Neil, Leanne Dawe, Andreas Roos, Vladimir Ljubicic, Alexander MacKenzie, Aymeric Ravel‐Chapuis, Hanns Lochmüller

This study shows that acute AMPK activation fails to improve insulin signaling in DM1 mouse and human models, indicating impaired insulin resistance mechanisms.

bioRxiv · Nov 4, 2025 · PreprintMolecular Biology

Gene-specific response to MuSK agonist antibody in the treatment of Congenital Myasthenic Syndromes

Kelly Ho, Ofosu Adjei-Afriyie, Ricardo Carmona-Martinez, Rohan Ray, Daniel O’Neil, Joshua Zeldin, Julien Oury, Lieselot De Clercq, Steven J. Burden, Bernhardt Vankerckhoven, Roeland Vanhauwaert, Sally Spendiff, Hanns Lochmüller

This study tests a MuSK agonist antibody in Agrn-CMS and ColQ-CMS mouse models, showing benefit in Agrn-CMS but not ColQ-CMS, highlighting gene-specific treatment responses.

bioRxiv · Aug 29, 2025 · PreprintMolecular Biology