Leucine zipper-based sorting system enables generation of multi-functional CAR T cells
Scott E. James, Sophia Chen, Brandon D. Ng, Jacob S. Fischman, Lorenz Jahn, Alexander P. Boardman, Adhithi Rajagopalan, Harold Kunal Elias, Alyssa Massa, Dylan Manuele, Katherine B. Nichols, Amina Lazrak, Nicole MynYi Lee, Teng Fei, Susan DeWolf, , Marcel R.M. van den Brink
This paper introduces a leucine zipper-based sorting system to generate T cells with multiple CARs and switch receptors, enhancing their ability to target heterogeneous tumors.
bioRxiv · Sep 13, 2023 · PreprintSynthetic Biology