Marcel R.M. van den Brink

The paper links sugar-rich foods to microbiome disruption during antibiotic treatment in patients and mice.

This study shows that higher dietary fiber intake improves survival and reduces GVHD in hematopoietic cell transplant patients, with microbiome-mediated effects.

This study compares the effects of two GVHD prophylaxis regimens on the gut microbiome in allo-HCT recipients and finds that while PTCy reduces microbiome diversity and bile acid metabolism, it is linked to better clinical outcomes.

The paper identifies galectin-3 as a target for nanotherapeutic delivery of ruxolitinib to reduce GVHD-related kidney injury and systemic inflammation.

This study shows that IL-18, generated in the thymus after tissue damage, limits thymic regeneration by targeting TECs, suggesting IL-18 as a therapeutic target and highlighting potential off-target effects in cancer immunotherapy.

This paper shows that pretransplant targeting of TNFRSF25 and CD25 with a TL1A-Ig fusion protein and low-dose IL-2 expands recipient Tregs, reducing GVHD after HSCT while preserving GVL.

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

The paper introduces FLORAL, a method for analyzing longitudinal microbiome data to identify biomarkers associated with time-varying outcomes, showing improved sensitivity and FDR control in simulations and real-world applications.

FLORAL improves microbial feature selection for microbiome data by addressing survival endpoints, longitudinal samples, and sequencing biases, showing better false-positive control and sensitivity in simulations and real data.

This study shows that pentanoate, a microbial postbiotic, is metabolized to citrate, which influences T cell differentiation and anti-cancer CAR T cell efficacy through epigenetic mechanisms.

This paper introduces a leucine zipper-based sorting system to generate T cells with multiple CARs and switch receptors, enhancing their ability to target heterogeneous tumors.

This study presents a paired tumor:normal sequencing dataset for hematologic malignancies, showing improved identification of somatic variants and their clinical relevance.

The paper compiles shotgun metagenomic data from stool samples of hospitalized hematopoietic cell transplant patients to enhance microbiome analysis beyond taxonomic composition.