Leveraging autophagy and pyrimidine metabolism to target pancreatic cancer
Suzanne Dufresne, Ramya S. Kuna, Kristiana Wong, Anvita Komarla, Louis R. Parham, Celina Shen, Payel Mondal, Adelaida Estrada-Cardenas, Angelica E. Rock, Joel Encarnación-Rosado, Amanda Cyril, Ginevra Doglioni, Dhanya R. Panickar, Nicole A. Bakas, Douglas J. Sheffler, , Christina G. Towers
This study identifies metabolic adaptations in pancreatic cancer cells resistant to autophagy inhibitors and shows that targeting pyrimidine salvage can enhance treatment efficacy.
bioRxiv · May 29, 2025 · PreprintCancer Biology