Christian M. Metallo

This study identifies an IL-10/ACOD1 axis that reprograms lipid metabolism in trained macrophages to promote resolution of inflammation.

This study shows that human astrocytes have distinct metabolic profiles compared to non-human primate astrocytes, which influence neuronal development timing and trajectories.

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

The paper uses 13C metabolic flux analysis on PDAC tumor slice cultures to identify metabolic pathways supporting glycosphingolipid synthesis and highlight the role of PIKfyve in lipid homeostasis.

This study introduces CL-MFA to quantify lipid metabolic fluxes in NSCLC models, revealing LKB1 regulation of sphingolipid recycling and fatty acid synthase upregulation under standard culture conditions.

This study shows p53 enables lipid headgroup recycling during senescence by increasing phosphoethanolamine supply through autophagy and lysosomal catabolism, revealing a metabolic vulnerability in p53-activated cells.

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

This study identifies serine dehydratase (Sds) as a regulator of serine and sphingolipid metabolism, showing that its deletion improves skin repair in diabetic mice.

This study uses mass spectrometry and in vivo 13C tracing to show itaconate is rapidly cleared from plasma, excreted in urine, and metabolized in the liver and kidneys.

This study identifies metabolic adaptations in pancreatic cancer cells resistant to autophagy inhibitors and shows that targeting pyrimidine salvage can enhance treatment efficacy.

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

The paper develops a method to quantify acyl-chain diversity in isobaric compound lipids using UHPLC-MS and validates it with metabolically engineered adipocytes.

The paper develops a method to screen oncogenic genes across multiple lineages using teratomas and identifies drivers of proliferation in specific cell types.