Fixed-dose streptozotocin combined with high-fat diet induces a stable type 2 diabetes-like phenotype in C57BL/6J mice
Claes Fryklund, Christian Simonsson, Alexandra Hellberg, Josefin Malmberg, Karin G. Stenkula, Maria Swanberg
This study shows that fixed-dose streptozotocin in HFD-fed mice induces a stable T2D-like phenotype, contrasting with weight-adjusted dosing which causes variability.
Disease Models & Mechanisms · Aug 6, 2026Peer-reviewedPhysiology